Ashley P. Tsang

Hello! I am a third-year Bioinformatics PhD Candidate at the University of Michigan, advised by Prof. Arvind Rao.

Previously, I obtained my Bachelor’s degree in BME & CS and Master’s degree in BME from Johns Hopkins University. While there, I was fortunate to work with Prof. Elana Fertig and Prof. Denis Wirtz.

My research interest lies at the intersection of AI and biology. I’m passionate about developing computational methods to study the spatial organization of cancer, particularly leveraging spatial multi-omics to characterize the tumor microenvironment and identify novel biomarkers of disease.

Please feel free to reach out if you’d like to chat further!

Selected Publications

Encoding functional edges in graphs to model spatially varying relationships in the tumor microenvironment
Ashley P Tsang(*), Santhoshi N Krishnan(*), Reva Kulkarni, Sagnik Bhadury, Marina Pasca di Magliano, Timothy L Frankel, Arvind Rao
Accepted to npj Artificial Intelligence, 2026
(*) indicates joint first authors

Assessing the tumor immune landscape across multiple spatial scales to differentiate immunotherapy response in metastatic non-small cell lung cancer
Ashley P Tsang(*), Santhoshi N Krishnan(*), Joel N Eliason(*), Jake J McGue, Angel Qin, Timothy L Frankel, Arvind Rao
Laboratory Investigation, 2024
[Journal]
(*) indicates joint first authors

Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R, and GenePattern Notebook implementations of CoGAPS
Jeanette A I Johnson(*), Ashley P Tsang(*), Jacob T Mitchell, Emily F Davis-Marcisak, Thomas Sherman, Ted Liefeld, Melanie Loth, Loyal Goff, Jacquelyn Zimmerman, Ben Kinny-Köster, Elizabeth Jaffee, Pablo Tamayo, Jill Mesirov, Michael Reich, Elana J Fertig, Genevieve L Stein-O’Brien
Nature Protocols, 2023
[Journal][Code]
(*) indicates joint first authors